Our memory can be influenced by factors originated outside of the brain. For instance, heart insufficiency can contribute to memory decline. However, the underlying molecular mechanism is unknown. Moreover, drugs that improve cardiac function have failed to reinstate memory once it is impaired. In this study, we have found a gene network that is conserved in other neurodegenerative diseases and underlies the heart insufficiency induced cognitive decline. Moreover, an epigenetic drug could reinstate the gene expression and revive the lost memory. The details are available in the following pre-print.